![]() ![]() Once inside, NMN is converted by cellular enzymes to create NAD.” Cells have evolved a receptor for NMN - it’s a special protein on the surface of the cell which attaches to NMN and shuttles it into the cell. “However, it can be done by providing the starting material for NAD, which is NMN. “We now know that it can’t be done by delivering NAD either orally or by IV - because NAD has no mechanism for entering the cell. “The real breakthrough that occurred recently is our understanding of how to get NAD levels closer to those of our youth,” says Professor Andrew Salzman, MD, a Harvard Medical School alumni and a prominent drug inventor who’s leading NAD and NMN research at Wonderfeel®. Recent research has found that taking NAD as a supplement doesn’t lead to the same potential benefits - but taking NMN can. ![]() More research on the benefits of NMN and NAD is needed. It’s important to note that these benefits were found for NAD, not for NMN specifically. Studies in older mice have shown that high blood NAD levels helped improve muscle function, strength, and endurance in older mice. Research suggests NAD may help adjust your internal clock, potentially helping ease jet lag or other circadian rhythm disorders. Elevated NAD levels may help protect cells against oxidative stress and DNA damage, which are associated with cancer development. Research in mice has found that high NAD levels in the blood reversed age-related arterial damage, which may help guard against heart disease. It may help reduce heart disease risk.These cellular stressors are related to some neurological diseases, including Alzheimer’s disease. NAD is thought to modulate the production of a protein that helps guard cells against impairment of mitochondrial function and oxidative stress. It may have protective effects on the brain.On the flip side, low-NAD levels are associated with age-related diseases. The activity of sirtuins is linked to longevity. In your cells, NAD activates a group of proteins called sirtuins, which help repair your DNA. Studies investigating NAD shed light on its potential benefits: Since taking NMN may help your body produce more NAD, it’s also important to consider the research behind the benefits of NAD. NR is another molecule similar to NMN that people also take as a supplement for healthy aging.Įvidence suggests that the body converts NR into NMN, which then is converted into NAD. If you’ve heard of NMN, you might have also heard of nicotinamide riboside (NR). Test-tube and animal studies also suggest that NMN may play a role in other aspects of aging, including heart and brain health. This may contribute to some of the health effects you might experience during aging.įor example, research has shown that people with different age-related conditions, including diabetes and liver diseases, may have lower levels of NMN and NAD. Your NMN levels naturally decline over time, and, as a result, your levels of NAD decline, too. It’s essential that your cells have plenty of NMN to produce enough NAD to support these functions. NAD helps cells regulate a number of essential functions that help keep your cells running smoothly, including: All the cells in your body use NAD and therefore require NMN, its precursor, to function properly. ![]()
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